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Letters to the Editor
August 2009

Premature Recommendation of Corticotropin-Releasing Hormone as Screen for Postpartum Depression

Arch Gen Psychiatry. 2009;66(8):915-917. doi:10.1001/archgenpsychiatry.2009.101

Yim and colleagues1 recently reported a positive association between maternal plasma levels of corticotropin-releasing hormone (CRH) at midpregnancy with risk of maternal depression at roughly 9 weeks postpartum. Their longitudinal cohort of 100 women yielded 16 cases of postpartum depression (PPD) at 9 weeks postpartum, as measured by the Edinburgh Postpartum Depression Scale with a threshold of 10 or greater to indicate probable minor depression. Yim and colleagues conclude that “midpregnancy pCRH [placental CRH] is a sensitive and specific early diagnostic test for PPD symptoms.’’1(p162)

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