Hippocampal atrophy has previously been reported in both postmortem and magnetic resonance imaging (MRI) studies in patients with schizophrenia compared with normal controls.1- 3 The neuroanatomic specificity of this finding for schizophrenia, however, remains to be determined. We have recently completed a small MRI study that suggests the following: (1) that this abnormality occurs in patients with schizophrenia but not in patients with bipolar disorder; and (2) that the amygdala may be enlarged in patients with bipolar disorder compared with both patients with schizophrenia and healthy control subjects. Herein we describe our preliminary findings.
Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J. Amygdala Enlargement in Bipolar Disorder and Hippocampal Reduction in Schizophrenia: An MRI Study Demonstrating Neuroanatomic Specificity. Arch Gen Psychiatry. 1998;55(7):663-664. doi: