February 1960

Stimulus Deprivation and Phospholipid Metabolism in Cerebral Tissue

Author Affiliations

Departments of Biological Chemistry and Pharmacology, Hahnemann Medical College of Philadelphia.

AMA Arch Gen Psychiatry. 1960;2(2):171-173. doi:10.1001/archpsyc.1960.03590080047007

Introduction  Isolation stress is now a recognized important problem involved in simulated and anticipated space flights and presents an urgent contemporary challenge for solution(s). Studies in human isolation are presently an integral part of the basic researches of space medicine and psychiatry.1-3 The effects of isolation, i.e., stimulus deprivation, are observable as deviant behavior in man1 and also in laboratory animals.4 Barnes5 has indicated that modern neuropharmacological agents, especially chlorpromazine, inhibited up to 90% of the abnormal behavior responses developed by rats and mice placed in solitary isolation for 7 to 10 days. Previous studies from these laboratories6,7 demonstrated that drugs of the ataratic class inhibited, along with other biochemical systems, the turnover of cerebral phospholipids as measured by the incorporation of P32o-phosphate. The degree of inhibition was generally observed to be related

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