February 1960

Urinary Aromatic Excretion Patterns in Schizophrenia

Author Affiliations

New York
From the Department of Biochemistry, Hillside Hospital, Glen Oaks, N.Y. (Drs. Goldenberg and Fishman); the Creedmoor Institute for Psychobiologic Studies, Queens Village (Dr. Whittier), and the Creedmoor State Hospital (Dr. Brinitzer).

AMA Arch Gen Psychiatry. 1960;2(2):221-230. doi:10.1001/archpsyc.1960.03590080097013

Introduction  A considerable body of information has appeared in the last three decades dealing with blood and urinary aromatic metabolites in schizophrenia.1 These studies were provoked, in earlier years, by impressive evidence for an aberrant metabolism of aromatic amino acids in one well-defined mental syndrome (phenylpyruvic oligophrenia). The more recent interest in this subject derives from the discovery of powerful psychotomimetic agents, such as d-lysergic acid diethylamide, which can provoke transient mental symptoms in otherwise normal subjects. The feature common to these agents is the presence of an aromatic chemical structure, either the benzene or the indole nucleus.Attempts to establish the presence of similar or derived compounds in the body fluids of schizophrenics have not been uniformly successful. McGeer et al.2 initially confirmed Sano’s3 reports of excessive indole (indican) excretion in mental disease but later reversed their

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