January 1963

Inhibition and Disinhibition in Schizophrenics

Author Affiliations

Institute of Psychiatry (Maudsley Hospital), University of London.

Arch Gen Psychiatry. 1963;8(1):91-98. doi:10.1001/archpsyc.1963.01720070093012

Part I  It has often been claimed that the normal inhibitory processes are in some manner disturbed in schizophrenia. Pavlov13 for example, asserted that schizophrenics have a predominance of inhibitory potential. Venables and Tizard15 suggest that schizophrenics show "an exaggerated tendency to develop reactive inhibition," and Ley9 concludes that they dissipate reactive inhibition very slowly. The Venables-Tizard and Ley statements can be regarded as attempts to develop Pavlov's position by making it more specific. These 2 proposals may be restated briefly.1. Schizophrenics develop reactive inhibition* rapidly.2. Schizophrenics dissipate reactive inhibition slowly.In the present study we are concerned Primarily with Statement 2; the evidence relating to Statement 1 is provided by various writers.3,6,7,12,16The dissipation of reactive inhibition is measured indirectly, by the reminiscence method. The rationale for this method2 is, briefly, that postrest increments in Perform

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