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February 1963

Energy Production and Premorbid History in Schizophrenia

Author Affiliations

From the Lafayette Clinic and Wayne State University College of Medicine.
Assistant Professor, Psychiatry, and Assistant Director, Lafayette Clinic (Dr. Beckett); Assistant Professor, Psychology, and Head, Division of Research Design, Lafayette Clinic (Dr. Senf); Assistant Professor, Physiological Chemistry, and Head, Biochemistry Laboratories, Lafayette Clinic (Dr. Frohman); Professor and Chairman, Department of Psychiatry, and Director, Lafayette Clinic (Dr. Gottlieb).
This study was supported in part by a grant-in-aid from the committee on Research of the Supreme Council, 33d Degree Scottish Rite Freemasonry, Northern Masonic Jurisdiction.

Arch Gen Psychiatry. 1963;8(2):155-162. doi:10.1001/archpsyc.1963.01720080045007

This report is one of a series on intermediary carbohydrate metabolism in schizophrenia. In previous communications the biochemical systems under investigation and the methods used have been discussed, and group differences between control, acute schizophrenic, and chronic schizophrenic male subjects have been reported.2,10 As part of the ongoing research program these initial results have been followed by an exploration in detail of the relationship between the biochemical measures and the clinical features of schizophrenia. Ratings of various aspects of the clinical picture have been made and Pearson product-moment correlation coefficients (r's) computed between these ratings and the biochemical measures. Some of these results have already been reported; it has been noted that one important adenine phosphate in the system under investigation, fructose 1-6 diphosphate (F1-6P), is related to the primary symptoms, and another adenine phosphate, adenosine triphosphate (ATP), to measures of .chronicity.2,4 The

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