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November 1963

Short-Term Effect of Psychotropic Drugs on Platelets

Author Affiliations

From the Creedmoor Institute for Psychobiologic Studies and the Biochemical Research Laboratory, Children's Unit, Creedmoor State Hospital.
Associate Research Scientist, Psychiatry (Dr. Haydu).

Arch Gen Psychiatry. 1963;9(5):510-512. doi:10.1001/archpsyc.1963.01720170084013

It was observed by Ballerini and Cantelli,1 and also by Huser et al,5 that serotonin administration to animals produces an increase of the circulating thrombocytes. Many of the psychotropic drugs in use have antiserotonin activity. It was of interest therefore when one of us (L. N.) noted increase of the circulating thrombocytes in the hemograms of patients who receive chlorprothixene. Chlorprothixene is a potent peripheral antiserotonin agent. It has 12 times the antiserotonin activity of chlorpromazine. We decided to examine the shortterm effect of four psychotropic drugs used routinely in psychiatric practice. These drugs were chlorpromazine, chlorprothixene, tranylcypromine, and imipramine. Tranylcypromine is a potent monoamine oxidase in hibitor. Imipramine is an antidepressant with antiserotonin properties.

Materials and Methods

Four groups of patients were formed. Each group consisted of eight hospitalized psychotic cases in which the respective drugs were required for

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