April 1964

Schizophrenia: 6-Hydroxyskatole and Environment

Author Affiliations

Assistant Professor of Medicine (Dr. Dohan), Associate Professor of Psychiatry (Dr. Ewing), School of Medicine; Fellow of the Institute of Neurological Sciences (Dr. Graff), University of Pennsylvania; Chief Research Biochemist, Veterans Administration Hospital (Dr. Sprince).
Veterans Administration Hospital, Coatesville, Pa; The Institute of the Pennsylvania Hospital; Mercy-Douglass Hospital; Department of Medicine, Department of Psychiatry; School of Medicine, Department of Biochemistry; Graduate School of Medicine, University of Pennsylvania, Philadelphia.

Arch Gen Psychiatry. 1964;10(4):420-422. doi:10.1001/archpsyc.1964.01720220098015

Numerous investigators have reported that hospitalized mentally ill patients were more likely to excrete 6-hydroxyskatole sulfate (6 HSK-OS) in the urine than "normal" individuals of the same age group.1-4 Others have reported large amounts in the urine of patients with the malabsorption syndrome.5

The meaning of these findings is not clear. Environmental factors have been suspected since it occurs more frequently and in greater amounts in various types of patients housed in mental hospitals. This paper reports: (1) A statistically significant degree of agreement for the presence or absence of 6 HSK-OS in the urine extracts of members of the same "normal" households. (2) The detection of 6 HSK-OS in the urine extracts of only 3 of 9 acute schizophrenics not previously treated in a mental hospital. (3) The detection of 6 HSK-OS in the urine extracts of only one of seven

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