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March 1967

Antibody Response to Cholera VaccineDifferences Between Depressed, Schizophrenic, and Normal Subjects

Author Affiliations

Rochester, NY
From the Departments of psychiatry and pediatrics, University of Rochester Medical Center, Rochester, NY.

Arch Gen Psychiatry. 1967;16(3):312-315. doi:10.1001/archpsyc.1967.01730210052009

THE FACT that relatively few individuals who harbor potentially pathogenic microorganisms actually develop clinical disease reflects the balance that usually exists between the host and the infectious agent. Disruption of this host-parasite relationship may result from defects in antibody production, severe leukopenia, dysfunction of other known host defenses, or the administration of adrenocortical hormones. More commonly, the factors which predispose a particular individual to develop clinically apparent infection are unknown. The possibility that psychological factors might influence host susceptibility by modifying the physiological status of the individual has been reviewed elsewhere.1 One approach to this problem has been to examine the incidence of somatic illnesses in psychiatric patients,2 and other investigations have sought some measurable parameter which would reflect the relative resistance of such patients to infectious disease.3-9 The present study is an attempt to evaluate the immunological

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