September 1967

Sleep Deprivation and EEG Slow Wave Activity in Chronic Schizophrenia

Author Affiliations

From the Lafayette Clinic and Wayne State University School of Medicine, Detroit.

Arch Gen Psychiatry. 1967;17(3):361-364. doi:10.1001/archpsyc.1967.01730270105014

THE STUDY of all-night sleep electroencephalographic patterns has emerged as the new "Sutters's field" of research in the behavioral sciences. For its application to the investigation of normal sleep physiology, we are indebted to the pioneering efforts of Dement and Kleitman.1 The extension of this technique to the study of psychosis was rapidly accomplished with results which appear to be promising. Because of the early emphasis upon rapid eye movement, sleep, and its correlation with dreaming, this sleep stage received the initial scrutiny. Although intriguing theoretical relationships have been drawn between schizophrenia and dreaming,2 schizophrenic patients could not be distinguished from nonpsychotic control subjects utilizing their stage 1-REM as a criterion.3 Caldwell and Domino,4 however, examined slow sleep activity in the all-night records of 25 chronic schizophrenic subjects who had been free of

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