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Article
April 1968

High Dose Chlorpromazine Therapy in Chronic SchizophreniaReport of National Institute of Mental Health—Psychopharmacology Research Branch Collaborative Study Group

Author Affiliations

Washington, DC
From the Psychopharmacology Research Branch, National Institute of Mental Health (Drs. Prien and Cole), and the Biometric Laboratory, George Washington University, Washington, DC (Dr. Prien).

Arch Gen Psychiatry. 1968;18(4):482-495. doi:10.1001/archpsyc.1968.01740040098013
Abstract

THIS STUDY on the efficacy of high dose chlorpromazine treatment in chronic schizophrenia was developed under the National Institute of Mental Health (NIMH) psychopharmacology program during 1964 and was initiated in seven collaborating public mental hospitals early in 1965. The hospitals participating in this study were Boston State Hospital, Boston; Broughton State Hospital, Morganton, NC; Dorothea Dix State Hospital, Raleigh, NC; Kentucky State Hospital, Danville, Ky; Manhattan State Hospital, New York; St. Louis State Hospital, St. Louis; and Springfield State Hospital, Sykesville, Md. These hospitals were selected to represent the entire urbanrural continum. Three hospitals admitted patients exclusively from large urban centers, two hospitals served areas which included both urban and rural communities, and two hospitals served areas which were almost exclusively rural.

Background  During the past 13 years, a large number of studies have been published on the use of chlorpromazine with chronic schizophrenic

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