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June 1968

Atypical Leukocyte Pattern of Schizophrenic Children

Author Affiliations

From the Ramsey Wright Zoological Laboratories, University of Toronto. Dr: Fowle is now at the Biology Department, York University, Toronto.

Arch Gen Psychiatry. 1968;18(6):666-680. doi:10.1001/archpsyc.1968.01740060026004

THERE ARE in the literature reports of investigations of the leukocytes in the peripheral blood of adult schizophrenic patients.1-6 Fessel and Hirata-Hibi2 described three types of abnormal leukocytes which they felt were related to the disease. How ever, Fieve et al6 have suggested that "these atypical lymphocytes are probably a phenothiazine drug effect, and not a function of the schizophrenic process."

During the past three years, the author has prepared and examined blood smears from schizophrenic children, some of whom had received phenothiazine drugs. The purposes of this paper are as follows: (1) to report the finding and frequency of several types of atypical leukocytes in the peripheral blood of children diagnosed as schizophrenic; (2) to report the frequency of these atypical leukocytes in the peripheral blood of schizophrenic children under continuous treatment with phenothiazine drugs; (3) to show the

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