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November 1968

Anti-Rabbit Heterophile Hemolysin and Agglutinin in Human SerumFailure to Corroborate Previous Observations on Schizophrenics

Author Affiliations

New York
From the Research Division, Central Islip State Hospital, Long Island, NY.

Arch Gen Psychiatry. 1968;19(5):616-618. doi:10.1001/archpsyc.1968.01740110104013

IN AN EARLIER publication in the ARCHIVES OF GENERAL PSYCHIATRY1 we reported the occurrence in human serum of an antibody which hemolyses rabbit erythrocytes. We reported that when a large number of persons, including patients at this hospital, patients in general medical-surgical hospitals, and healthy controls, were studied, a bimodal distribution of hemolysin level was found. Over 70% of schizophrenics but less than 25% of controls gave sera with titres above the low point of the distribution. During two years of work on this system, these findings were extended, with a final N of 616 and a χ2 of 111 differentiating schizophrenics from all other groups.

Two other laboratories were unable to confirm our observations. At a third laboratory, differences in hemolysin titre were found to be related to a difference in time of mixing serum and erythrocytes and in the subsequent

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