IN A SERIES of related papers by Mattsson et al,1 Williams et al,2 and Lipman et al,3 a Symptom Distress Check List (SCL), developed by Parloff, Frank, and their coworkers,4,5 containing items covering the spectrum of common psychoneurotic complaints, was factor-analyzed, employing the self-ratings of more then 1,500 anxious-neurotic outpatients. These Factors were tested for their sensitivity in discriminating pharmacologic and nonpharmacologic influences within the context of a double-blind, placebo-controlled trial of meprobamate in which doctor medication attitudes were experimentally manipulated via role-playing techniques.6
Of the five stable and clinically meaningful factors extracted from the patients' selfratings, Somatization and Fear-Anxiety proved most sensitive to main drug effects, whereas the remaining three factors—General Neurotic Feelings, Cognitive-Performance Difficulty, and Depression—were more reliably influenced by the interaction of pharmacologic and nonpharmacologic variable in the treatment context.
Lipman RS, Chase C, Rickles K, Covi L, Derogatis LR, Uhlenhuth EH. Factors of Symptom DistressDoctor Ratings of Anxious Neurotic Outpatients. Arch Gen Psychiatry. 1969;21(3):328-338. doi:10.1001/archpsyc.1969.01740210072009