INCREASED activity of the enzymes creatine phosphokinase (CPK) (E.C.220.127.116.11) and aldolase (E.C.18.104.22.168) has been reported in the serum of acutely psychotic patients of all diagnostic types: acute schizophrenic patients, manic-depressive patients, and patients with psychotic depression.1-5 Chronically psychotic patients, schizophrenic or depressed, did not have any increase in the activity of these enzymes even when they were experiencing an exacerbation of their psychosis which necessitated rehospitalization.3-5 Nonpsychotic severely anxious or depressed hospitalized psychiatric patients also had no increase in the activity of these enzymes.
The increased activity of CPK or aldolase, or both, was generally present at the onset of a psychotic episode in the acute patients and lasted for five to ten days after hospitalization, but could be as brief as 1 day or, in one instance, as long as 51 days.3,4 The increased enzyme activities ranged
Meltzer H, Elkun L, Moline RA. Serum-Enzyme Changes in Newly Admitted Psychiatric PatientsPart I. Arch Gen Psychiatry. 1969;21(6):731-738. doi:10.1001/archpsyc.1969.01740240091011