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November 1970

Ocular Changes Occurring With ProlongedResults From a Collaborative Study

Author Affiliations

Washington, DC; Boston
From the Biometric Laboratory, George Washington University (NIMH-PRB Collaborative Studies on Chronic Schizophrenia), Washington, DC (Dr. Prien), Boston State Hospital (Boston) (Dr. Cole), and the Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Md (Drs. Levine and Delong). Dr. Prien is currently with the Central Neuropsychiatric Laboratory, VA Hospital, Perry Point, Md.

Arch Gen Psychiatry. 1970;23(5):464-468. doi:10.1001/archpsyc.1970.01750050080011

SINCE 1964 there have been numerous reports on lenticular and corneal opacities in patients treated with chlorpromazine.1-9 These changes are well described in the literature. The lenticular opacities consist of granular deposits in the axial portion of the anterior capsule. When the change is mild, granules are small and assume a disciform distribution. In more advanced cases, the granules tend to accumulate along the suture lines and assume a stellate pattern with a dense central area and radiating branches. Corneal changes consist primarily of diffuse granular deposits at the posterior surface. In severe cases, the granularity may spread into the posterior third of the corneal stroma. These corneal changes rarely occur in the absence of lens change and appear to be proportional to the severity of the lens opacities.

Recently, opacities of the anterior cornea have been found in patients treated with chlorpromazine.10,11 This change,

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