Pseudocyesis probably represents only one position along a spectrum of aberrations of psychoneuroendocrine control of the gonads. Amenorrhea is often mentioned as a symptom of depression. Other menstrual disturbances of unknown etiology which are usually classified as hypothalamic amenorrhea might also be a part of this spectrum. The connection between depression and alterations in gonadal function may have further psychophysiological implications. This could, in part, be due to the sequence of neuroendocrine events associated with depression, leading to decreased FSH and LH secretion from the anterior pituitary. Future studies using these constructs will be of use in further clarifying psychological and neuroendocrinological relationships.
Brown E, Barglow P. PseudocyesisA Paradigm for Psychophysiological Interactions. Arch Gen Psychiatry. 1971;24(3):221-229. doi:10.1001/archpsyc.1971.01750090027004