April 1971

Plasma Cortisol Response to Dexamethasone Suppression in Depressed and Control Patients

Author Affiliations

New York
From the Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, New York.

Arch Gen Psychiatry. 1971;24(4):320-326. doi:10.1001/archpsyc.1971.01750100030004

Adrenocortical overactivity as a theory in the pathogenesis of depression cannot be supported on the basis of this study. Plasma cortisol response to dexamethasone was normal in both bipolar and unipolar depressives, reactive depressives and schizophrenics. As a group, schizophrenics showed significantly higher morning cortisol values than the depressed population.