In a four-year period 115 manic-depressive patients were seen and subsequently followed over a period of 17.8 years. Sixty-five patients had recovered, 24 patients had improved, and 22 had not fully recovered. Several factors may be related to an unfavorable course in manic-depressive illness. More women than men did not recover. Prognosis was somewhat poorer in those patients with mania only, or both manic and depressive attacks of the illness. A history of paranoid delusions seemed to point to a poor prognosis. The prognosis in manic-depressive illness is relatively favorable.
Shobe FO, Brion P. Long-term Prognosis in Manic-Depressive IllnessA Follow-up Investigation of 111 Patients. Arch Gen Psychiatry. 1971;24(4):334-337. doi:10.1001/archpsyc.1971.01750100044006