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June 1971

EEG and Behavioral Effects of Drug Therapy in ChildrenChlorpromazine and Diphenhydramine

Author Affiliations

New York; New Orleans; New York
From the departments of psychiatry and neurology, New York University Medical Center (Drs. Korein, Fish, and Shapiro and Miss Levidow), Bellevue Medical Center (Drs. Korein and Fish), and the Department of Neurology, US Public Health Service Hospital, New Orleans (Dr. Gerner). Dr. Korein is a Health Research Council Career Scientist of the city of New York.

Arch Gen Psychiatry. 1971;24(6):552-563. doi:10.1001/archpsyc.1971.01750120068012

The results of a double-blind study evaluating the EEG and behavioral effects of chlorpromazine hydrochloride and dyphenhydramine hydrochloride on 29 children indicate that EEG findings alone can show whether or not a child is receiving medication. There was also a significant correlation between the more marked clinical behavior changes and the more marked EEG changes. The EEG effects of both drugs included slow alpha waves and generalized slowing, in the case of diphenhydramine hydrochloride, high voltage 4 to 6 cycle per second activity was uniformly produced by the relatively high doses used in this study.