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August 1971

Life History and Symptoms in SchizophreniaSeverity at Hospitalization and Response to Phenothiazines

Author Affiliations

Chevy Chase, Md
From the Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Md.

Arch Gen Psychiatry. 1971;25(2):138-147. doi:10.1001/archpsyc.1971.01750140042008

Data regarding social background of 480 newly hospitalized schizophrenic patients were gathered by social workers as part of a multihospital study of phenothiazine effectiveness. Ninety-seven specific characteristics were examined in relation to clinical ratings of symptom severity at hospitalization and improvement. Aspects of patients' childhood family background and circumstances surrounding the process of hospitalization were related to symptom severity at the point of hospitalization, but the amount of improvement seen after five weeks of treatment was related to variables which measured level of role functioning and attainments. Where treatment effects were seen, response to fluphenazine hydrochloride was more marked among patients who showed characteristics traditionally regarded as unfavorable. Acetophenazine maleate served to enhance the effects of favorable prognostic indicators.