During a double-blind, placebo-controlled study, imipramine hydrochloride was administered to 35 nonpsychotic school-phobic children. The children and their families were given a multidiscipline treatment program, concurrently with imipramine or placebo treatment. Imipramine, administered over a six-week period, was found significantly superior to placebo in inducing school return, and in global therapeutic efficacy. Doses of medication ranged from 100 to 200 mg /day. Imipramine effects could not be detected after three weeks of therapy.
Gittelman-Klein R, Klein DF. Controlled Imipramine Treatment of School Phobia. Arch Gen Psychiatry. 1971;25(3):204–207. doi:10.1001/archpsyc.1971.01750150012002