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September 1971

Controlled Imipramine Treatment of School Phobia

Author Affiliations

Glen Oaks, NY
From the Research Department, Hillside Hospital, Glen Oaks, NY.

Arch Gen Psychiatry. 1971;25(3):204-207. doi:10.1001/archpsyc.1971.01750150012002

During a double-blind, placebo-controlled study, imipramine hydrochloride was administered to 35 nonpsychotic school-phobic children. The children and their families were given a multidiscipline treatment program, concurrently with imipramine or placebo treatment. Imipramine, administered over a six-week period, was found significantly superior to placebo in inducing school return, and in global therapeutic efficacy. Doses of medication ranged from 100 to 200 mg /day. Imipramine effects could not be detected after three weeks of therapy.