The attempt in one hospital to model a drug study after the NIMH nine-hospital collaborative study resulted in a useful modification in which relatively small numbers of newly admitted, acutely exacerbated chronic schizophrenic patients were studied for a period of four weeks. Statistically significant drug: placebo differences were easily detected on most psychiatric and behavioral variables, but not on the psychological performance tasks used. The overall design appears to be suitable for sequential analysis and might provide the basis for an early screening program for antipsychotic drugs in which very small numbers of subjects would be required for relatively short periods of observation. A possible differential drug response favoring thioridazine over chlorpromazine hydrochloride and fluphenazine hydrochloride on several variables was not statistically significant.
Clark ML, Huber WK, Charalampous KD, Serafetinides EA, Trousdale W, Colmore JP. Drug Treatment in Newly Admitted Schizophrenic Patients. Arch Gen Psychiatry. 1971;25(5):404-409. doi:10.1001/archpsyc.1971.01750170020004