February 1972

Cortisol Production in Mania

Author Affiliations

New York
From the departments of psychiatry (Dr. Sachar) and oncology (Dr. Hellman) and the Institute for Steroid Research (Drs. Fukushima and Gallagher), Montefiore Hospital and Medical Center, and the departments of psychiatry (Dr. Sachar), medicine (Dr. Hellman), and biochemistry (Drs. Fukushima and Gallagher), Albert Einstein College of Medicine, New York.

Arch Gen Psychiatry. 1972;26(2):137-139. doi:10.1001/archpsyc.1972.01750200041009

Cortisol production rate was determined by isotope dilution analysis in seven unanxious hypomanic patients during illness and after lithium-carbonate-induced remission. There was no significant change in cortisol production, and all values were in the normal range. There was also no change for the group in the excretion of cortisol metabolites.