February 1973

Provocation of Schizophrenic Symptoms by Intravenous Administration of Methylphenidate

Author Affiliations

Nashville, Tenn
From the departments of psychiatry and pharmacology, Vanderbilt University School of Medicine and the Tennessee Neuropsychiatric Institute, Nashville, Tenn.

Arch Gen Psychiatry. 1973;28(2):185-191. doi:10.1001/archpsyc.1973.01750320023004

Methylphenidate (Ritalin) hydrochloride was administered intravenously to schizophrenic, manic, and depressed patients during the active phase of their illness and upon recovery and to normal. Methylphenidate was found to activate psychotic symptoms in schizophrenics during the active phase of their illness. It failed to produce this effect in the same patients after remission had occurred. It failed to produce a psychotic reaction in most patients with mania and all normal or depressed patients.