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March 1973

Impairment of Optokinetic Nystagmus in Patients With Tardive Dyskinesia

Author Affiliations

From the Neurological Unit, Boston State Hospital.

Arch Gen Psychiatry. 1973;28(3):331-333. doi:10.1001/archpsyc.1973.01750330031005

Impaired or absent optokinetic nystagmus was observed significantly more frequently among patients with tardive dyskinesia than among nondyskinetic control subjects. In view of known abnormal ocular motor responses in patients with Parkinson disease and Huntington chorea, this finding may be a consequence of chronic chemical denervation of dopamine receptors in the striatum.