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March 1973

Hallucinogenic Drug-Induced Behavior Under Sensory AttenuationPrediction of Response to Psilocybin

Author Affiliations

From the departments of psychiatry and pharmacology, the College of Medicine, Ohio State University, Columbus, and the Maryland Psychiatric Research Center, Baltimore.

Arch Gen Psychiatry. 1973;28(3):434-438. doi:10.1001/archpsyc.1973.01750330106017

Eight "stable" and four "variable" college-age subjects were given 160μg/kg psilocybin under conditions of sensory attenuation. Stability was defined by the magnitude of the standard deviation on handwriting area under predrug conditions.

Only the variable subjects, our large-standard deviants, responded to the drug with a significant decrease in mean pulse rate and increase in handwriting area. They also reported consistently more intense experiences under psilocybin than the small-standard deviants. The degree of variability on perceptual-behavioral measures, such as the SD on handwriting area, is significantly related to, and therefore a predictor of, the intensity of the ensuing drug-induced experience.