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July 1973

THR (Lopremone): Psychobiological Responses of Normal WomenI. Subjective Experiences

Author Affiliations

Chapel Hill, NC
From the Department of Psychiatry, Medical School and the Biological Sciences Research Center, University of North Carolina, Chapel Hill (Drs. Prange and Lipton), and the Division of Research, North Carolina Health Department, Raleigh, NC (Drs. Wilson, Lara, Alltop, and Stikeleather).

Arch Gen Psychiatry. 1973;29(1):15-21. doi:10.1001/archpsyc.1973.04200010006001

Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart in a double-blind study. After saline, somatic symptoms and mental changes were negligible. After lopremone, subjects experienced a variety of somatic symptoms, usually within a few minutes of injection.

Later they experienced relaxation, mild euphoria, and a sense of increased energy. Since correlation analyses showed that intensity of euphoria was not related to frequency of side-effects and was negatively related to magnitude of thyrotropin (thyroid stimulating hormone, TSH) response, euphoria presumably did not arise solely from suggestion or from thyroid stimulation.