Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart. Lopremone injection caused a sharp rise in thyrotropin (thyroid stimulating hormone, TSH) levels with a return to near-base line levels in three hours. These TSH responses were slightly greater than those previously elicited in depressed women but the difference was statistically insignificant. After lopremone injection, triiodothyronine (T3) levels rose more and sooner than thyroxine (T4) levels.
Neither TSH elevation nor thyroid hormone elevation correlated with the euphoric response experienced by most subjects. This and other evidence suggests a central action of lopremone.
Prange AJ, Wilson IC, Lara PP, Wilber JF, Breese GB, Alltop LB, Lipton MA. THR (Lopremone): Psychobiological Responses of Normal WomenII. Pituitary-Thyroid Responses. Arch Gen Psychiatry. 1973;29(1):28-32. doi:10.1001/archpsyc.1973.04200010015002