August 1973

Lithium Retention in Mania

Author Affiliations

USN; Oakland, Calif
From the Neuropsychiatry Service, Naval Hospital, Oakland, Calif. Dr. Taylor is currently with the Department of Psychiatry, New York Medical College, New York City.

Arch Gen Psychiatry. 1973;29(2):232-234. doi:10.1001/archpsyc.1973.04200020062008

Evaluating lithium retention requires measurement of serum and urinary excretion lithium ion levels over a specified period of time following a single orally administered dose of lithium carbonate. We report the lithium retention of a matched group of acute manic patients and normal controls. Our results confirm earlier work suggesting that acute manic patients retain significantly more orally administered lithium ion than normal controls; that this difference is detectable by comparing amounts of lithium ion excreted in the urine, but not by comparing serum concentrations; and that this retention difference is apparent as early as six hours after the test dose administration and increases over a limited time.