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Article
October 1973

Chlorpromazine Treatment of Disturbed Monkeys

Author Affiliations

Madison, Wis; Nashville, Tenn
From the Department of Psychiatry and Primate Laboratory (Dr. McKinney), the Department of Psychiatry (Dr. Young), the University of Wisconsin School of Medicine, Madison; the Department of Psychology, the University of Wisconsin, Madison (S. Suomi); and the Department of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn.

Arch Gen Psychiatry. 1973;29(4):490-494. doi:10.1001/archpsyc.1973.04200040042007
Abstract

Four rhesus monkeys which were subjected to partial social isolation during the first 11 months of life and which had consistently exhibited patterns of grossly abnormal behavior during the 1½ years prior to the current study were treated with chlorpromazine.

Three of the four subjects showed significant decreases in their self-disturbance behaviors on 7.5 mg/day of chlorpromazine given as the liquid concentrate by nasogastric intubation. The fourth subject showed no change. Plasma chlorpromazine levels confirmed absorption of the drug in all subjects.

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