This study attempted to confirm earlier reports that antibody titers to the herpes simplex virus were significantly elevated in patients with depressive illness and psychopathic disorder. One hundred ninety-seven subjects were studied, including 62 patients with a diagnosis of depression and 29 patients with antisocial personality or emotionally unstable personality disorder.
The methods of antibody assay included measurement of neutralizing antibodies and complement-fixation antibodies. No significant elevation of herpesvirus type I antibodies was found in either the depressive group or the personality disorder group. The incidence of antibody positive subjects and the titer levels tended to increase with age.
Pokorny AD, Rawls WE, Adam E, Mefferd RB. Depression, Psychopathy, and Herpesvirus Type I AntibodiesLack of Relationship. Arch Gen Psychiatry. 1973;29(6):820-822. doi:10.1001/archpsyc.1973.04200060092014