January 1974

The Use of Cyclazocine in Treating Narcotic Addicts in a Low-Intervention Setting

Author Affiliations

New Haven, Conn
From the Department of Psychiatry, Yale University School of Medicine and the Drug Dependence Unit, Connecticut Mental Health Center, New Haven.

Arch Gen Psychiatry. 1974;30(1):37-42. doi:10.1001/archpsyc.1974.01760070023004

This study evaluated the clinical efficacy of cyclazocine when used as part of a direct-service drug-abuse program characterized by relatively low-treatment intervention. Standard induction and maintenance schedules were devised and procedures were developed to evaluate results.

Twenty-seven patients were administered cyclazocine over a tenmonth period with 42% being retained. Results suggest that, although cyclazocine was accepted by a majority (75%) of the sample, the nature and extent of side effects during induction may limit its usefulness of a larger scale. The overall program design holds promise as a model for future use of narcotic antagonists.