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January 1974

L-Tryptophan in ManiaContribution to a Permissive Hypothesis of Affective Disorders

Author Affiliations

RN, Raleigh, NC
From the Department of Psychiatry, School of Medicine, and the Biological Sciences Research Center, University of North Carolina, Chapel Hill (Dr. Prange), and the Division of Research, North Carolina Mental Health Department, Dorothea Dix Hospital, Raleigh (Drs. Wilson and Lynn, Mr. Alltop, and Ms. Stikeleather).

Arch Gen Psychiatry. 1974;30(1):56-62. doi:10.1001/archpsyc.1974.01760070040006

Five manic patients were treated with chlorpromazine hydrochloride (CPZ), then with L-tryptophan (LTP), and five with LTP first, then CPZ, in a double-blind, placebo-controlled crossover study. LTP was slightly superior to CPZ in all regards. Mania and depression may be linked by a central indoleamine deficit.