The effect of lithium carbonate on electroencephalographic sleep parameters was evaluated in six patients with affective disorders. Confirming earlier results, we report significant reductions in rapideye-movement (REM) percent and phasic-REM activity during the drug period. Doubling of delta-sleep time occurred during lithium administration, and a negative correlation between REM percent and delta percent was found; there was no immediate REM compensation in the postdrug period. We propose a model for REM suppression based on REM-cycle length and the presence or absence of REM rebound.
Kupfer DJ, Reynolds CF, Weiss BL, Foster FG. Lithium Carbonate and Sleep in Affective DisordersFurther Considerations. Arch Gen Psychiatry. 1974;30(1):79-84. doi:10.1001/archpsyc.1974.01760070061009