February 1974

A Follow-Up of Monozygotic Twins Discordant for Schizophrenia

Author Affiliations

Bethesda, Md
From the Section on Twin and Sibling Studies, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. Dr. Cohen is currently with the Department of Psychiatry, University of Vermont, Burlington, Vt.

Arch Gen Psychiatry. 1974;30(2):219-222. doi:10.1001/archpsyc.1974.01760080073012

A series of 17 monozygotic twins discordant for schizophrenia was studied intensively at the National Institute of Mental Health between 1963 and 1967. Sixteen pairs were interviewed a mean of 7.8 years after original admission.

It was found that one pair is now concordant for schizophrenia, three previously healthy co-twins show new psychopathology of a possibly schizophrenic nature, and 12 twin pairs remain stably discordant.