In a controlled (crossover) study a group of phobic neurotic psychiatric outpatients were treated with standard systematic desensitization aided by intravenously administered methohexital sodium (Brevital Sodium). Results show that desensitization is effective in reducing the severity of phobic symptoms. Methohexital-aided desensitization may be significantly superior to conventional systematic desensitization in causing greater improvement of the phobic symptoms during an equal time period. The dosage range of intravenously administered methohexital sodium used in this study (up to 60 mg per 50 minute session) was found to be extremely safe and practical for outpatient use.
Razani J. Treatment of Phobias by Systematic DesensitizationComparison of Standard vs Methohexital-Aided Desensitization. Arch Gen Psychiatry. 1974;30(3):291-293. doi:10.1001/archpsyc.1974.01760090011002