The main objective of this paper was to relate tardive dyskinesia to the total intake of neuroleptics.
The data were based on a selected sample of geriatric patients, on accurate and complete information on chemotherapy, and on three neurological examinations.
A 7-point rating scale was used to distinguish drug-induced from spurious motor abnormalities. Two statistical approaches demonstrated that the risk of oral dyskinesia increases with the exposure to neuroleptics.
Crane GE, Smeets RA. Tardive Dyskinesia and Drug Therapy in Geriatric Patients. Arch Gen Psychiatry. 1974;30(3):341-343. doi:10.1001/archpsyc.1974.01760090055009