July 1974

Effect of Prolonged Chlorpromazine Administration on the Sleep of Chronic Schizophrenics

Author Affiliations

Washington, DC
From the Laboratory of Clinical Psychopharmacology, IRP, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC.

Arch Gen Psychiatry. 1974;31(1):62-66. doi:10.1001/archpsyc.1974.01760130044007

The sleep of 13 chronic male schizophrenics was studied during a one-month trial of chlorpromazine and compared with one-month placebo periods. Electroencephalographic recordings were made only after the patients had been on chlorpromazine hydrochloride or a placebo for at least three weeks.

Sleep latency and awake time were significantly decreased on chlorpromazine while stage II, delta sleep, delta%, nonrapid eye movement (NREM) sleep, REM activity, REM latency, and REM density were significantly increased. There were no significant changes in REM time, REM%, stage II%, and NREM%.