Patients with schizophrenia often do not take their prescribed phenothiazines. This survey focused on the drug-taking behavior of 85 mostly chronic schizophrenic patients during a two-year period.
Thirty-nine (46%) of these patients took less antipsychotic drug than the amount prescribed. The reluctance to take antipsychotic medication was significantly associated with extrapyramidal symptoms—most notably a subtle akathisia.
It is proposed that drug reluctance and dysphoric response to antipsychotic drugs are often extrapyramidally based.
Van Putten T. Why Do Schizophrenic Patients Refuse to Take Their Drugs?. Arch Gen Psychiatry. 1974;31(1):67-72. doi:10.1001/archpsyc.1974.01760130049008