July 1974

A Family Interview Study of Male Manic Depressives

Author Affiliations

St. Louis
From the Department of Psychiatry, Washington University School of Medicine, St. Louis. Dr. Winokur is now with the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

Arch Gen Psychiatry. 1974;31(1):73-77. doi:10.1001/archpsyc.1974.01760130055009

Thirty male manic probands and their first-degree relatives were investigated by means of a systematic psychiatric interview in order to determine the frequency of familial illness and possible mode of transmission of bipolar manic-depressive disorder. The infrequency of male-to-male transmission of affective disorder and the relative preponderance of the illness on the maternal side of the family both support similar previous findings that are suggestive of sex linkage in this illness. The incidence of alcoholism was found to be high and more prevalent on the paternal side of the families.