[Skip to Content]
[Skip to Content Landing]
Article
August 1974

Drowsiness Due to Chlorpromazine in Relation to Cigarette SmokingA Report From the Boston Collaborative Drug Surveillance Program

Author Affiliations

From the Boston Collaborative Drug Surveillance Program (BCDSP), Boston University Medical Center.

Arch Gen Psychiatry. 1974;31(2):211-213. doi:10.1001/archpsyc.1974.01760140063010
Abstract

The frequency of drowsiness attributed to orally administered chlorpromazine hydrochloride was compared among 130 nonsmokers and 201 "light" and 72 "heavy" cigarette smokers. Drowsiness occurred in 16%, 11%, and 3%, respectively. More rapid metabolism of chlorpromazine in cigarette smokers may explain these findings.

×