This is the first report in a projected series on neurological development among the offspring of schizophrenics. An increased incidence of fetal and neonatal deaths is noted among offspring of schizophrenics when compared to a closely matched control group, using data collected prospectively.
In many cases, no apparent reason for death was determined; in some cases, major neurological malformations were found. It is necessary to consider three possible explanations for these findings—genotype of the child, adverse intrauterine environment, and medication toxicity.
Rieder RO, Rosenthal D, Wender P. The Offspring of SchizophrenicsFetal and Neonatal Deaths. Arch Gen Psychiatry. 1975;32(2):200-211. doi:10.1001/archpsyc.1975.01760200064006