March 1975

Accuracy of the Family History Method in Affective IllnessComparison With Direct Interviews in Family Studies

Author Affiliations

From the Department of Medical Genetics, New York State Psychiatric Institute (Drs. Mendlewicz and Rainer); Columbia University College of Physicians and Surgeons (Drs. Mendlewicz, Rainer, and Fleiss); the Biometrics Research Unit, New York State Department of Mental Hygiene (Dr. Fleiss); and Rockland State Hospital, New York (Ms. Cataldo).

Arch Gen Psychiatry. 1975;32(3):309-314. doi:10.1001/archpsyc.1975.01760210043002

We interviewed available spouses and first-degree relatives of 140 bipolar and unipolar probands for current and past psychopathology, and assessed interrater reliability. Diagnoses based on direct interviews of relatives were compared with those based on reports of the probands and of all other interviewed family members. Probands underestimated the prevalence of affective illness and other psychiatric disorders in their relatives, and overestimated the age of onset of illness in their ill relatives. Probands reported more accurately about illness in their spouses and parents than in their siblings and children, but accuracy reached acceptable levels for spouses only.

Diagnoses on relatives derived by combining reports of all other interviewed family members, including the proband, were slightly more accurate than those based on the proband's reports alone. Good accuracy was obtained only for reports about spouses.