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July 1975

Acute ManiaClinical and Genetic Study of Responders and Nonresponders to Treatments

Author Affiliations

From the Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook.

Arch Gen Psychiatry. 1975;32(7):863-865. doi:10.1001/archpsyc.1975.01760250055005

We examined the relationships among family history of psychiatric illness, demographic and historical variables, clinical course and presentation, and treatment response for 58 patients satisfying research criteria for mania. Nearly two thirds of the group had excellent responses to somatic treatment, particularly lithium ion, while one third had poor responses to lithium carbonate, neuroleptics, or electric convulsive therapy.

Responders frequently exhibited euphoric moods, grandiose delusions, and tended to have cyclothymic premorbid personalities. Nonresponders were rarely euphoric, frequently exhibited incomplete auditory hallucinations, and tended to have formal thought disorder and depressive-withdrawn premorbid personalities. Responders tended (nonsignificant) to have greater genetic loading for affective illness and alcoholism. We could not distinguish the two groups by their age at illness onset, duration of illness, or number of illness episodes per ill patient year.