August 1975

Dopamine-Sensitive Adenylyl Cyclase in Human Caudate NucleusA Study in Control Subjects and Schizophrenic Patients

Author Affiliations

From the Laboratory of Preclinical Pharmacology (Drs. Carenzi, Guidotti, and Trabucchi), and the Laboratory of Clinical Psychopharmacology (Drs. Gillin and Wyatt), National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC. Dr. Schwartz is now with the New York Hospital Cornell Medical Center, White Plains.

Arch Gen Psychiatry. 1975;32(8):1056-1059. doi:10.1001/archpsyc.1975.01760260120010

Striatal adenylyl cyclase activity from autopsied human brain is selectively stimulated by low concentrations of dopamine. Under the experimental conditions used, norepinephrine was about three times less potent than dopamine. Histamine and serotonin were ineffective. The stimulation by dopamine was competitively inhibited by haloperidol. There was no difference between the basal adenylyl cyclase activity or its level after dopamine stimulation between nine control subjects without a psychiatric history and seven patients with chronic schizophrenia.