• Ten endogenous depressive patients were deprived of sleep for two whole nights according to the following schedule: sleep/sleep deprivation/sleep/sleep deprivation/sleep. No drugs were administered. Experimental conditions were as neutral as possible. Blind and nonblind ratings were taken.
The patients were generally rated as improved after sleep deprivation, but a substantial effect, though temporary with rapid relapse, occurred in only two cases. After subsequent sleep, relapse followed as a rule. The net antidepressive effect of the total procedure was slightly more than nil.
van den Burg W, van den Hoofdakker RH. Total Sleep Deprivation on Endogenous Depression. Arch Gen Psychiatry. 1975;32(9):1121-1125. doi:10.1001/archpsyc.1975.01760270053005