September 1975

Total Sleep Deprivation on Endogenous Depression

Author Affiliations

From the Department of Biological Psychiatry, Psychiatric University Clinic, State University, Groningen, Netherlands.

Arch Gen Psychiatry. 1975;32(9):1121-1125. doi:10.1001/archpsyc.1975.01760270053005

• Ten endogenous depressive patients were deprived of sleep for two whole nights according to the following schedule: sleep/sleep deprivation/sleep/sleep deprivation/sleep. No drugs were administered. Experimental conditions were as neutral as possible. Blind and nonblind ratings were taken.

The patients were generally rated as improved after sleep deprivation, but a substantial effect, though temporary with rapid relapse, occurred in only two cases. After subsequent sleep, relapse followed as a rule. The net antidepressive effect of the total procedure was slightly more than nil.