[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.197.124.106. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 1975

Psychiatric Illness in Fathers of Men With Bipolar Primary Affective Disorder

Author Affiliations

From the Department of Internal Medicine, New York State Psychiatric Institute; and the Department of Psychiatry, Columbia University, New York.

Arch Gen Psychiatry. 1975;32(9):1134-1137. doi:10.1001/archpsyc.1975.01760270066007
Abstract

• A systematic interview regarding family history was administered to 48 men with bipolar affective illness who were attending a lithium clinic. Several families were found in which both the patient and his father had affective disorders, but the mother and maternal second-degree relatives were well. Of 30 men who had histories of hospitalization for mania, three had fathers with affective disorder (all bipolar). Of 18 men who had depression and hypomania, one father had unipolar depressive disorder. The hypothesis that bipolar manic-depressive illness may be transmitted by a single dominant genetic factor on the X chromosome is discussed in relation to these ill father—ill son pairs.

×