• Previous work with chronic schizophrenic patients and a pilot study with nonchronic treatment-refractory schizophrenic patients indicated that very high doses of fluphenazine hydrochloride (1,200 mg/day) have a greater antipsychotic effect than do standard doses. Increased side-effects were not reported. In a double-blind six-week random assignment study, 18 nonchronic treatment-refractory patients received the very high dose and 13 the standard dose.
The standard-dose treated patients had greater improvement on a variety of measures. Analysis of Inpatient Multidimensional Psychiatric Scale scores indicated that some patients taking very high doses had akinesia, an extrapyramidal side-effect that in part accounted for their inferior response.
Quitkin F, Rifkin A, Klein DF. Very High Dosage vs Standard Dosage Fluphenazine in SchizophreniaFrederic Quitkin, MD; Arthur Rifkin, MD; Donald F. Klein, MD. Arch Gen Psychiatry. 1975;32(10):1276-1281. doi:10.1001/archpsyc.1975.01760280074007