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April 1976

Schizophrenia—A Follow-up Study of Results of TreatmentI. Design and Other Problems

Author Affiliations

From the Department of Program Evaluation, Research, and Education (Dr May) and the Statistical Research Unit (Dr Dixon), Veterans Administration Hospital, Brentwood, Calif; the Neuropsychiatric Institute (Dr May) and the Health Sciences Computing Facility (Dr Dixon), University of California at Los Angeles; and the Clinical Research Branch (Dr Tuma) of the National Institute of Mental Health, Rockville, Md.

Arch Gen Psychiatry. 1976;33(4):474-478. doi:10.1001/archpsyc.1976.01770040042008

• This is the first of a series of articles on a follow-up study of the results of treatment of schizophrenia, studied over a period of two to five years after first admission and first release. The study compares the follow-up outcome of five different treatment methods given to first-admission male and female schizophrenic patients in the hospital.

The design of the study is used as a basis for description and discussion of the practical, ethical, and statistical problems involved. A distinction is made between follow-up and continued treatment design, and it is concluded that both pose massive problems in execution, analysis, presentation, and interpretation.